Southern Indiana Vacations from $492

Book a Hotel + Flight or Car together to unlock savings

Your Southern Indiana Vacation

Make planning your next big adventure a breeze with a Southern Indiana vacation package. Whether it's nature, history or something else that draws you here, our packages will help you discover it all. A trip to Southern Indiana wouldn't be complete without exploring some of its leading cities, starting with Louisville. A couple of the most popular attractions here include KFC Yum Center and Kentucky Kingdom. Evansville is another favorite with Southern Indiana travelers. Visitors to this destination enjoy Ford Center and Bally's Evansville Casino. When you're ready to stop daydreaming and start doing, Expedia will help turn your Southern Indiana vacation into a reality.

The Latest Southern Indiana vacation packages

Price found within the past 48 hours. Click for updated prices.
21c Museum Hotel Cincinnati

21c Museum Hotel Cincinnati

Downtown Cincinnati
$492
per person
Nov 27 - Nov 30
found 14 hours ago
Roundtrip flight included
Dallas (DFW) to Cincinnati (CVG)
8.6/10 Excellent! (1,006 reviews)
The Purple Martin

The Purple Martin

$803
per person
Dec 3 - Dec 6
found 1 day ago
Roundtrip flight included
Newark Liberty Intl. Airport (EWR) to Louisville (SDF)
10/10 Exceptional! (2 reviews)
Amazing property… I would come back in a heartbeat!

Reviewed on Jun 19, 2025

Hyatt Regency Louisville

Hyatt Regency Louisville

Downtown Louisville
$560
per person
Nov 18 - Nov 21
found 1 day ago
Roundtrip flight included
Dallas (DFW) to Louisville (SDF)
8.8/10 Excellent! (1,007 reviews)
Was close to all activities walking distance

Reviewed on Sep 21, 2026

The Grady

The Grady

Downtown Louisville
$788
per person
Nov 23 - Nov 28
found 1 hour ago
Roundtrip flight included
Dallas (DAL) to Louisville (SDF)
9.4/10 Exceptional! (1,005 reviews)
Great property in the heart of downtown Louisville. Our room was well-appointed and service was great.

Reviewed on Sep 21, 2026

The Brown Hotel

The Brown Hotel

Downtown Louisville
$704
per person
Nov 23 - Nov 28
found 8 hours ago
Roundtrip flight included
Dallas (DAL) to Louisville (SDF)
9.4/10 Exceptional! (1,289 reviews)
Classic clean and very historical

Reviewed on Sep 22, 2026

Don't see what you're looking for?
See all available trips from Columbus to Southern Indiana
View all trips

Where to stay in Southern Indiana

Find the best Southern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southern Indiana
The entrance to the Kentucky Science Center with a large circular structure in the foreground.

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

A historic building with a prominent clock tower and dome, surrounded by trees and modern buildings.

Downtown Evansville

2 out of top 10 points of interest in this area

Dive into the cultural hub of Evansville, where you can catch a performance by the Evansville Philharmonic Orchestra at Victory Theatre or explore the Children's Museum of Evansville. Don't miss the LST-325 Museum and Ford Center nearby!

Default Image

Madison Historic District

If you're spending some time in Madison Historic District, Historic District and Lanier Mansion are top sights worth seeing.

A bridge with a metal truss structure and a highway with vehicles.

Portland

While visiting Portland, you might make a stop by sights like Portland Museum and Lannan Park Trailhead.

An aerial view of a park with manicured lawns, a central fountain, and a large building with a red dome.

Downtown French Lick

While Downtown French Lick might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like French Lick Springs Hotel and French Lick Casino.

Stay near popular Southern Indiana attractions

A river with a bridge, a stadium, and modern buildings.

KFC Yum Center

8.8/10 (1,621 reviews)
This waterfront arena hosts Louisville's premier sporting events and world-class concerts with 22,000 seats. Arrive early to explore downtown's culinary scene before experiencing the vibrant atmosphere inside.
See properties
A water slide with a yellow and green inflatable raft carrying three people.
Photo by Indiana Office of Tourism Development

Holiday World and Splashin' Safari

9.4/10 (294 reviews)
Holiday World features themed holiday areas with thrilling coasters and water attractions. Enjoy complimentary soft drinks and sunscreen while experiencing the world's longest water coaster, Wildebeest.
See properties
A wooden barrel room with barrels lined up on both sides and a wooden floor.

Whiskey Row

9.2/10 (11 reviews)
Find out about the history of Louisville when you spend time at Whiskey Row. Attend a sporting event or simply enjoy the lively bars while you're in the area.
See properties
A tall wooden baseball bat leaning against a brick building with a sign reading "Hillerich & Brassler Co."

Louisville Slugger Museum

9.2/10 (2,299 reviews)
Step inside the world's only Louisville Slugger factory where baseball history comes alive. Watch craftsmen transform raw wood into iconic bats, then hold the same models used by legends like Babe Ruth and Derek Jeter.
See properties
A city street with a large building labeled "FOURTH STREET" and a neon sign for "JIM BEAM."
Photo by Nura Mirzaliyeva

Fourth Street Live!

8.4/10 (2,560 reviews)
Louisville's premier entertainment district offers a vibrant mix of restaurants, bars, and live music venues. Savor diverse culinary experiences and dynamic nightlife in this pedestrian-friendly downtown hub.
See properties

Kentucky International Convention Center

8.4/10 (763 reviews)
Downtown Louisville's premier venue, KICC impresses with its modern glass design and light-filled spaces. Attend conventions, trade shows, and exhibitions in this state-of-the-art facility at the heart of the city.
See properties

Ford Center

8.4/10 (472 reviews)
Downtown Evansville's premier arena hosts Purple Aces basketball, Thunderbolts hockey, and major concerts. With cushioned seating for up to 11,000 spectators, it offers comfortable viewing and diverse concession options.
See properties

Bally's Evansville Casino

8.0/10 (505 reviews)
Indiana's first casino offers scenic Ohio River views alongside a vibrant gaming experience. Enjoy upscale dining at Cavanaugh's while watching the river flow past your table.
See properties

Southern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

505 Marriott Drive Clarksville IN
Fully refundable
$76 nightly
$85 total
Sep 30 - Oct 1
Total with taxes and fees
7.2/10 Good! (3,394 reviews)
"this was my second time staying, both times have been great. it’s not a luxury hotel but it is nice. they have restaurant/bar, indoor and outdoor pool, plenty of places to sit and walk around. it’s fun just exploring. our room was clean for the most part. you can tell they don’t wipe down the walls ..."

Reviewed on Sep 23, 2026

Radisson Hotel Louisville North
Santas Lodge and Resort

Santas Lodge and Resort

91 W CHRISTMAS BLVD Santa Claus IN
Fully refundableReserve now, pay when you stay
$112 nightly
$126 total
Oct 23 - Oct 24
Total with taxes and fees
8/10 Very Good! (449 reviews)
"Awesome very friendly staff and a amazing staff and the breakfast was awesome Love this place"

Reviewed on Sep 21, 2026

Santas Lodge and Resort
Derby Hotel & Suites

Derby Hotel & Suites

505 K Marriot Dr Clarksville IN
Fully refundableReserve now, pay when you stay
$60 nightly
$67 total
Sep 28 - Sep 29
Total with taxes and fees
7/10 Good! (208 reviews)
"The room was clean, it served its purpose, however, the area was a bit sketchy, a lot of drug users in the area."

Reviewed on Sep 23, 2026

Derby Hotel & Suites
See all 1,653 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Find the Best Southern Indiana Vacation Packages

Things to do near Southern Indiana

Southern Indiana offers a delightful blend of outdoor adventures, picturesque scenery, and romantic getaways. Enjoy fun festivals, explore quirky roadside attractions, and visit popular tourism sites. You can indulge in body treatments or splash around at a local water park, making it a perfect destination for relaxation and excitement. Whether you're seeking a quiet retreat or thrilling activities, Southern Indiana has something for everyone.

Shopping

Discover the charming Jasper City Mill, located 10 miles from Southern Indiana, offering unique gifts and local crafts. Just 19 miles away, Antique Shak features a delightful selection of vintage treasures and collectibles, perfect for finding that special souvenir to remember your trip.

Recreation

Sultan's Run Golf Course offers a fantastic golfing experience with its scenic landscapes and challenging holes, perfect for outdoor enthusiasts. Meanwhile, Jim Yellig Park provides a tranquil setting for relaxation and wellness activities, allowing visitors to unwind amid nature. Jasper Municipal Golf Course also invites sports lovers to enjoy its beautiful fairways.

Adventure

The Ray Yellig Memorial Trail, located 21 miles from Southern Indiana, offers an exhilarating hiking experience. Immerse yourself in the breathtaking scenery as you traverse diverse landscapes, perfect for outdoor enthusiasts seeking adventure and a connection with nature.

Nightlife

Experience the vibrant nightlife of Southern Indiana at the lively River City Casino, where gaming and entertainment blend seamlessly. For a laid-back vibe, check out a local brewery like New Albanian Brewing Co., offering craft beers and a cozy atmosphere perfect for unwinding after a day of exploration.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Find the best attractions near Southern Indiana

Southern Indiana is perfect for outdoor and romantic getaways, offering a variety of attractions such as urban parks, visitor centers, and arts centers. Travelers can enjoy cultural experiences, family activities, and scenic views. Be sure to explore local tourist destinations and attractions to fully appreciate the charm of this region.

  • Dubois County Visitors Center: Located 9 miles from Southern Indiana, this center offers a gateway to adventure with its outdoor activities perfect for families. Explore local attractions, get travel tips, and enjoy the warm hospitality that embodies the spirit of Dubois County.
  • Thyen-Clark Cultural Center: Situated 10 miles away, this arts center is a cultural gem showcasing local art and performances. Experience the vibrant community through various exhibitions and events that celebrate the rich artistic heritage of the region.
  • St Joseph's Church: Just 9 miles from Southern Indiana, this historic church is not only a place of worship but also a stunning architectural landmark. Its serene atmosphere and beautiful design invite visitors to reflect and appreciate its cultural significance.

Best time to go to Southern Indiana

The best time to visit Southern Indiana is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately low and weather is mostly cloudy with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January33.1°F (0.6000000000000001°C)Light RainMostly CloudyModerately LowSlightly Low
February36.1°F (2.3000000000000003°C)Light RainMostly CloudyModerately LowSlightly Low
March46.2°F (7.9°C)Light RainMostly CloudyAverageSlightly Low
April55.8°F (13.2°C)Light RainMostly SunnyAverageAverage
May64.9°F (18.3°C)Light RainMostly SunnyAverageAverage
June74.3°F (23.5°C)Light RainMostly SunnyModerately HighSlightly High
July77.2°F (25.1°C)Light RainMostly SunnyModerately HighSlightly High
August75.9°F (24.4°C)Light RainMostly SunnyModerately HighSlightly High
September70.0°F (21.1°C)Light RainMostly SunnyAverageAverage
October58.1°F (14.5°C)Light RainMostly SunnyAverageAverage
November45.9°F (7.7°C)Light RainMostly SunnyAverageAverage
December37.8°F (3.2°C)Light RainMostly CloudyModerately LowAverage

Tips to save on your trip to Southern Indiana

  • Combine your flights, hotels and car rentals on Expedia—bundling can result in significant savings.
  • Consider traveling to Southern Indiana during the low season (January to March) for more affordable options.
  • Use the Price per traveler filter on Expedia to find a package deal that suits your budget.
  • Check the VIP Access properties filter to discover outstanding hotels with added member perks at select properties.

Southern Indiana Essential Information

Language
English
Currency
U.S dollars
Closest Airport
Cincinnati - Northern Kentucky Intl. Airport (CVG)

More vacations you might like

Explore a world of travel with Expedia

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.